• Meng et al reported hESC culture using

  2018-10-22

  

  Meng et al. (2008) reported hESC culture using HEScGRO xeno-free complete culture medium from Millipore and a feeder layer from human foreskin fibroblasts. However, they maintained the hESC by mechanical passaging of the colonies. For rapid expansion of hESC cultures, transfection, and clonal select

• In summary our work is an important step to

  2018-10-22

  

  In summary, our work is an important step to understand and to control phosphorylation dynamics in human pluripotent stem cell maintenance and differentiation. This is the first report that provides a detailed analysis of MAPKs regulation in hESC in response to a small molecule inhibitor. We have sh

• Our hiPSC RPE cell sheets met general requirements

  2018-10-22

  

  Our hiPSC-RPE cell sheets met general requirements, in terms of quality, quantity, consistency, and safety, for clinical-grade donor BMS-650032 intended for use in cell replacement therapy. These cell sheets expressed typical RPE markers, showed polarized secretion of PEDF and VEGF, and exhibited ph

• br The reactive epicardium in the non regenerative injury

  2018-10-20

  

  The ‘reactive’ epicardium in the non-regenerative injury response Following myocardial infarction (MI) in adult mammals, billions of CMs are lost and replaced by proliferation and activation of fibroblasts which deposit ECM (most notably collagen) which results in scar formation. Whilst required

• Adding to the growing repertoire of available cardiac

  2018-10-20

  

  Adding to the growing repertoire of available cardiac injury models for neonatal mice, Jesty et al. recently reported on the cardiomyogenic potential of neonatal mice following cryoinjury (Jesty et al., 2012). In response to cryoinfarction at 1–3days-of-age, neonatal mice underwent a marked cardiomy

• Cell motility is a complex physicochemical process that lead

  2018-10-20

  

  Cell motility is a complex physicochemical process that leads to the translocation of the chemokine receptor across two-dimensional (2D) surfaces, through basement membranes, or through three-dimensional (3D) interstitial tissues (Ridley et al., 2003). During cell movement through basement membrane

• An EMBO conference on cell therapy and

  2018-10-20

  

  An EMBO conference on cell therapy and its clinical applications The topics Given the broad and sometimes ill-defined distinctions among the various disciplines, we decided to focus on both allogeneic and autologous genetically corrected cell therapy, with the exclusion of “in vivo” gene therapy

• br Funding This work was supported by a

  2018-10-20

  

  Funding This work was supported by a grant from the Dutch Technology Foundation STW (project 10507). Disclosures Acknowledgments Introduction Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia in patients with bilateral lung infiltrates. The Berlin defin

• Epinastine HCl CD A KLS cells express

  2018-10-20

  

  CD11A KLS Epinastine HCl express multiple markers of endothelial cells (EPCR, VE-cadherin, and CD34), suggesting that they are recently derived from the endothelial lineage and raising the question of whether they retain endothelial cell potential and contain hemogenic endothelium. Whereas we did no

• sglt-2 CD A KLS cells express

  2018-10-20

  

  CD11A KLS sglt-2 express multiple markers of endothelial cells (EPCR, VE-cadherin, and CD34), suggesting that they are recently derived from the endothelial lineage and raising the question of whether they retain endothelial cell potential and contain hemogenic endothelium. Whereas we did not obser

• br Experimental Procedures br Acknowledgments br

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Hepatitis C virus (HCV) infects an estimated 2%–3% of the world population and is a major cause of liver disease and cancer. It is estimated that more than 350,000 people die of the HCV-related liver disease each year (Te and Jensen, 2010

• In order to clarify such method dependent

  2018-10-20

  

  In order to clarify such method-dependent reprogramming hallmarks, we applied standard assays to compare polycistronic cassettes (constructed in-house or obtained from public resources) in a drug-inducible piggyBac (PB) transposon reprogramming system. The induced expression of various polycistronic

• Although the use of iPSC derived neurons offer a number

  2018-10-20

  

  Although the use of iPSC-derived neurons offer a number of advantages because they are human derived and more closely resemble neurons than tumor cell lines, there are some limitations which should be considered (Gurwitz, 2016). They are expensive, do not grow indefinitely and require some level of

• br Results br Discussion Frequent

  2018-10-20

  

  Results Discussion Frequent tumor relapse in multiple tumor types has now been attributed to the presence of residual CSCs after conventional treatments. We and others have previously identified CD133 to mark a liver CSC subpopulation in HCC (Ma et al., 2007, 2010). Yet, the functional paths b

• In the absence of SOX stem

  2018-10-20

  

  In the absence of SOX2+ stem cells and Notch signaling in Rbp-Jf/f, Prop1-Cre mutant mice, the pituitary glands are hypoplastic and dysmorphic. Interestingly, re-entry of PIT1+ lineages into the ezh2 pathway after birth is delayed in the mutant. Consistent with our finding, reduced postnatal pituit

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