In order to clarify such method dependent

2018-10-20

In order to clarify such method-dependent reprogramming hallmarks, we applied standard assays to compare polycistronic cassettes (constructed in-house or obtained from public resources) in a drug-inducible piggyBac (PB) transposon reprogramming system. The induced expression of various polycistronic

Although the use of iPSC derived neurons offer a number

2018-10-20

Although the use of iPSC-derived neurons offer a number of advantages because they are human derived and more closely resemble neurons than tumor cell lines, there are some limitations which should be considered (Gurwitz, 2016). They are expensive, do not grow indefinitely and require some level of

br Results br Discussion Frequent

2018-10-20

Results Discussion Frequent tumor relapse in multiple tumor types has now been attributed to the presence of residual CSCs after conventional treatments. We and others have previously identified CD133 to mark a liver CSC subpopulation in HCC (Ma et al., 2007, 2010). Yet, the functional paths b

In the absence of SOX stem

2018-10-20

In the absence of SOX2+ stem cells and Notch signaling in Rbp-Jf/f, Prop1-Cre mutant mice, the pituitary glands are hypoplastic and dysmorphic. Interestingly, re-entry of PIT1+ lineages into the ezh2 pathway after birth is delayed in the mutant. Consistent with our finding, reduced postnatal pituit

Neuroanatomical studies indicate that DARPP neurons could be

2018-10-20

Neuroanatomical studies indicate that DARPP32+ neurons could be divided into two populations: one that constructs a direct pathway and another that constructs an indirect pathway. DARPP32+ neurons in the direct pathway express DRD1 and are located in the striosome. On the other hand, those in the in

br Results br Discussion In this study

2018-10-20

Results Discussion In this study we show that SOX2 repression in TCam-2 b-AP15 is due to the presence of PcG and H3K27me3 at its promoter and that the repression can be reversed by recruitment of UTX, a H3K27 demethylase to the promoter. SOX2 repression is a feature of hPGCs, from which SEM a

Finally we recognize that rodent models for

2018-10-20

Finally, we recognize that rodent models for intranasal delivery of NSCs have intrinsic limitations, such as the relative size and anatomical differences in the nasal and olfactory systems between humans and mice. Despite differences in the anatomy of the nasal cavity, larynx, and pharyngeal details

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions O.G. performed the analysis, visualization, qRT-PCR, and writing of the manuscript; K.M. carried out Hlf functional experiments; N.B. helped with the computational analysis; Y.G. performed the cell culture and functional assays; M.F. did some of the

Impaired neural migration and defects in

2018-10-20

Impaired neural migration and defects in the Sunitinib Malate cytoskeleton are well-known factors contributing to malformations during the cortical development (Pang et al., 2008). Reduced expression of NSUN2 in human NES cells impaired migration toward the chemoattractant FGF2. FGF2 is widely used

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2018-07-29