• br The identification of germline and

  2018-11-09

  

  The identification of germline and (/) mutations creates a unique opportunity to reduce the incidence of breast and ovarian cancer by providing appropriate screening and risk reducing prophylactic surgery options. Such downstream reductions in cancer incidence will only be successful if identifi

• Taken together these findings support future

  2018-11-09

  

  Taken together, these findings support future trials to investigate the utility of alternative drug regimens in patients with severe forms of extra-pulmonary TB, in whom inadequate drug penetration may contribute to poor outcome. There is increasing concern that the conventionally prescribed dose of

• br Conflict of interest br Acknowledgement br Introduction C

  2018-11-08

  

  Conflict of interest Acknowledgement Introduction Chicken meat is favoured by consumers around the world because of its desirable nutritional qualities, such as a low fat content and a relatively high concentration of polyunsaturated fatty acids [1]. Fresh meat products are usually marketed

• Third beyond fundamental and preclinical significance the im

  2018-11-08

  

  Third, beyond fundamental and preclinical significance, the importance of chimeric assays using nonhuman primates extends into the realm of invaluable research resources. Investigations using nonhuman primates are expensive and cumbersome, yet important to bridge the gap from fundamental discoveries

• The behaviour of viscoelastic materials is dependent upon co

  2018-11-08

  

  The behaviour of viscoelastic materials is dependent upon conditions such as temperature, pH and hydration (Mezger, 2006) therefore these parameters were kept constant throughout rheology measurements. Changes in the mechanical properties of our materials can be attributed to changes within the stru

• Cell adhesion to the ECM appears to

  2018-11-08

  

  Cell adhesion to the ECM appears to trigger various intracellular signaling pathways. In addition to proteolytic degradation of amniotic basement membrane components by proteases such as MMP-9, intracellular signaling cascades stimulated by growth factors or cytokines released from cell-cell matrix

• There exist two different known mechanisms of protein

  2018-11-08

  

  There exist two different known mechanisms of protein synthesis from mRNA template: cap-dependent and cap-independent translation initiation. The latter is driven by IRES element that was found in both viral RNAs and cellular mRNAs (Balvay et al., 2009; Shatsky et al., 2010). IRES element was origin

• One group has recently identified bone marrow

  2018-11-08

  

  One group has recently identified bone marrow (BM)-residing very small embryonic-like stem cells (VSELs) in both human and mouse as a putative nonembryonic source for PSCs (Drukała et al., 2012; Kucia et al., 2006b; Wojakowski et al., 2009; Zuba-Surma et al., 2011). Mouse VSELs have been characteriz

• 2-deoxy-d-glucose Translational controls have a central role

  2018-11-08

  

  Translational controls have a central role in the regulation of stem cell biology. The importance of translational regulations has been reported in mouse embryonic stem cells, which display a considerable increase in mRNA levels and translation during their differentiation (Sampath et al., 2008). In

• A potent methodology was recently developed to generate

  2018-11-08

  

  A potent methodology was recently developed to generate a highly enriched population of floor-plate-derived midbrain lineage ESC-mDA and iPSC-mDA neurons sufficient to treat the large PD patient population (Kriks et al., 2011). Cellular Dynamics International made a critical translational advancemen

• Inflammatory changes are observed in

  2018-11-08

  

  Inflammatory changes are observed in AD brains, particularly at the vicinity of senile plaques. They are abundant in activated microglia, which are the resident macrophages in the central nervous system, in both human AD samples (Mattiace et al., 1990; Perlmutter et al., 1990) and transgenic mouse m

• Cell motility is a complex physicochemical

  2018-11-08

  

  Cell motility is a complex physicochemical process that leads to the translocation of the UNC 0642 across two-dimensional (2D) surfaces, through basement membranes, or through three-dimensional (3D) interstitial tissues (Ridley et al., 2003). During cell movement through basement membranes or 3D tis

• br Materials and methods The

  2018-11-08

  

  Materials and methods The PQ embryos from in vitro fertilization were donated, and the fetal membranes were collected in accord with the INPER Ethics Committee (212250-21071) as well as the Guidelines for the Conduct of hESC Research (ISSCR, 2006). The hAEC were isolated and cultured from human

• From an evolutionary perspective the high level of

  2018-11-08

  

  From an evolutionary perspective, the high level of resistance of HSPCs to lentiviruses makes sense, since any major chromosomal vulnerability would have more serious implications than in progeny cells. The high-level expression of SAMHD1 in cultured HSPCs is reminiscent of the one in activated CD4+

• While we showed that endothelial cells and

  2018-11-08

  

  While we showed that endothelial protein kinase g and astrocytes contribute to the regulation in the neurogenic niche of the hippocampus, the role of pericytes is far less conclusive. For most time pericytes have received relatively little attention and only more recently their role in the context

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