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br Introduction Bone marrow adipocytes
2019-04-22

Introduction Bone marrow adipocytes are one of the most abundant cell types found in bone marrow tissue. They constitute approximately 15% of the bone marrow volume in young adults, rising to 60% by the age of 65 years old [1]. Previously considered as inert space filling cells with little biolog
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br Discussion Valproic acid is a potent inhibitor
2019-04-22

Discussion Valproic bet bromodomain is a potent inhibitor of histone deacetylases (HDAC). It can modify the structure of chromatin allowing recruitment of transcription factors to restore epigenetically suppressed genes. Valproic acid has been shown to possess antiproliferative activity and to o
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The primary tool in the pharmacological management of PTSD
2019-04-22

The primary tool in the pharmacological management of PTSD is the use of selective serotonin reuptake inhibitors [55,56], but positive response rates are generally limited. In addition, non-pharmacological treatment such as CBT has been shown to be effective for PTSD [57]. Psychological distress
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En diversos lugares de M
2019-04-22

En diversos lugares de México, como en Guerrero, el Valle del Mezquital, la región de Actopan, etc., según confirman las publicaciones del Instituto Nacional de Antropología e Historia de la ciudad de México, la creencia de que los huesos de los antepasados se convierten en piedras con propiedades e
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Actualmente los movimientos sociales est n desarrollando ya
2019-04-22

Actualmente, los movimientos sociales están desarrollando ya una importante función de “representación expresiva”, y transmiten puntos de identificación en una sociedad fragmentada que impugna al Estado y YO-01027 la sociedad sobre la exclusión y las desigualdades existentes. Justamente, el segundo
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Brasil y Argentina son los dos
2019-04-22

Brasil y Argentina son los dos países que comparten fronteras con todos los países restantes del bloque primigenio. Aun así, sus legislaciones abordan el tema en menor profundidad en comparación NSC59984 como lo hacen Paraguay y Uruguay. En Brasil, la Ley 11445 es la que refleja en cierta medida el
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br Prognosis The management of AML in the elderly patient
2019-04-22

Prognosis The management of AML in the elderly patient presents a significant challenge for hematologists. Careful evaluation of both patient and disease is required in each individual case to make optimal management decisions, and maximize the benefit to the patient. Apart from the extremely old
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Although high and variable frequencies of sickle
2019-04-22

Although high and variable frequencies of sickle cell trait in different ethnic groups in Uganda have been reported previously, those data were from around 70 years ago and were based on small sample sizes. Thus, the findings of Ndeezi and colleagues provide a contemporary overview that is nationall
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br Reflexiones finales En el presente art
2019-04-20

Reflexiones finales En el presente artículo hemos analizado a la Virgen de caacupé como proceso de construcción social identitaria. para ello hemos abordado el traslado y refundación de la devoción por parte de los migrantes paraguayos a la ciudad de San carlos de Bariloche. este proceso en tanto
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5-ht At baseline the patient exhibited normal A
2019-04-20

At baseline, the patient exhibited normal A–H (57ms) and H–V (44ms) intervals, with a sinus 5-ht length of 784ms. Both antegrade and retrograde dual atrioventricular (AV) nodal physiologies were assessed by atrial and ventricular extrastimulus (Fig. 2), without inducible AV nodal reentrant tachycar
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br Future perspectives Identification of LOX as
2019-04-20

Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “
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Human ether a go go related
2019-04-20

Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium EZ Cap Reagent AG that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being translate
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The most compelling apparent evidence in
2019-04-20

The most compelling apparent evidence in support of the depolarization hypothesis derives from the seminal studies of Nademanee et al. [129]. showing that radiofrequency ablation (RFA) of epicardial sites displaying late potentials and fractionated bipolar electrograms in the RVOT of patients with B
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De hecho en una cultura como la mexicana de mediados
2019-04-20

De hecho, en una cultura como la mexicana de mediados del siglo xix, en que predomina la iconografía y símbolos tradicionales del catolicismo, la Crucifixión es de importancia fundamental, entendida a lo largo de El fistol del diablo a nivel de sinécdoque, es decir, de la parte por el todo: la herid
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myosin inhibitor Gender transformative policy and cultural r
2019-04-20

Gender transformative policy and cultural reforms are also crucial to change prevailing norms and customs that devalue women and girls. Implementation and enforcement of non-discriminatory policies and practices that require gender equity in inheritance, property rights, education, and civil liberti
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