• br Acknowledgement Our work is supported

  2018-11-08

  

  Acknowledgement Our work is supported by research grants from the Agence Nationale de la Recherche (ANR; projects PLURABBIT no. PCS-09-GENM-08 and ORYCTOGENE no. ANR-12-RPIB-0013), European Cooperation in Science and Technology (COST) Action (Rabbit Genome Biology (RGB)-Net no. TD1101), HyPharm,

• The numbers of GFAP NSCs did not return

  2018-11-08

  

  The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

• Importantly we found that both HIF factors nonredundantly re

  2018-11-08

  

  Importantly, we found that both HIF factors nonredundantly regulate the morphology and behavior of primary mesenchymal progenitors: in the absence of HIFα expression PαS+ mesenchymal progenitors show impaired proliferation, colony forming ability, and differentiation and acquire an elongated and mot

• In conclusion our experimental setting allowed

  2018-11-08

  

  In conclusion, our experimental setting allowed the identification of differences in survival and proliferation pathways between PN and MES GSCs. The sensitivity of MES GSCs to the silencing of AXL highlights its importance in this subgroup of GSCs and suggests its potential for use as a therapeutic

• bcl-2 inhibitor br Conclusion In this study we have successf

  2018-11-08

  

  Conclusion In this study we have successfully generated iPSCs, and iPSC-derived retinal organoids, from patients with TRNT1-associated RP and used these bcl-2 inhibitor to investigate the underlying pathophysiologic mechanisms of disease. We have also identified disease-specific phenotypes that p

• br Experimental Procedures br Acknowledgments We thank Nadia

  2018-11-08

  

  Experimental Procedures Acknowledgments We thank Nadia Roan (UCSF) for critical reading of the manuscript; Jasmine Sosa (Stanford) for technical help; and Toshihiro Kobayashi and Toshinobu Nishimura (Stanford) for assistance with graphic design. This work was supported in part by funds from th

• Panobinostat Theoretically enhanced induction of TRA a speci

  2018-11-08

  

  Theoretically, enhanced induction of TRA1-60, a specific marker for reprogrammed iPSCs by miR-31 and shRNA-SDHA, can be achieved in two ways: improved reprogramming efficiency or inhibiting pariPSCs from differentiating back into somatic cells. We strongly favor the view that enhanced induction of T

• Introduction Raw water in South Africa is considered a strat

  2018-11-07

  

  Introduction Raw water in South Africa is considered a strategic national resource, with the responsibility for its management taking place at three tiers. These are firstly Central Government, secondly Provincial and Regional Governments, including other specified authorities, and thirdly Local Au

• We described the presence of dye and

  2018-11-07

  

  We described the presence of dye and electrical coupling in the RAS, specifically in the intralaminar parafascicular nucleus (Pf), the PPN, and the subcoeruleus dorsalis (SubCD), which modulates REM sleep [42–44]. We also found that the stimulant modafinil decreased the resistance of PPN, Pf, and Su

• stavudine Supplier M xico es el nico pa s

  2018-11-07

  

  México es el único país de América Latina en donde aumentó la pobreza, 60.6 millones de mexicanos que viven bajo la línea mínima de bienestar, lo afirma Alicia Bárcenas, Secretaria ejecutiva de la Comisión Económica para América Latina (cepal), en el Panorama social de América Latina y el Caribe del

• aromatase inhibitor br Discussion This study compares provir

  2018-11-07

  

  Discussion This study compares proviral DNA in the earliest stages of AHI between untreated vs. treated individuals in two cohorts with similar gender, ethnicity, setting, HIV subtype and baseline total and integrated HIV DNA values, and with the same HIV DNA quantification methods (Vandergeeten

• The authors addressed this question

  2018-11-07

  

  The authors addressed this question using a meta-analytic approach involving 15 studies that examined more than 12,000 smokers (). The study found that there were no differences in the benefits of quitting based on CHRNA5 allelic status. Consistent with many previous studies the benefits of quitting

• br Materials and Methods br Results br Discussion

  2018-11-07

  

  Materials and Methods Results Discussion In this study, we identified amino ampa changes in the gp41 MPER of CAP206 Envs that modulate neutralization sensitivity by antibodies that target multiple HIV-1 Env epitopes. Changes in the MPER of the CAP206 Env can be detected as early as 12month

• In the current issue of EBioMedicine describe the applicatio

  2018-11-07

  

  In the current issue of EBioMedicine, describe the application of a metabolomic platform based on bi-dimensional gas chromatography coupled to high-resolution mass spectrometry (GC×GC-TOF-MS) to identify biomarkers in serum samples that could associate with disease severity and predict the outcomes

• br Introduction Influenza comprises a substantial portion

  2018-11-07

  

  Introduction Influenza comprises a substantial portion of morbidity and mortality caused by acute respiratory infections, which are the fourth leading cause of death and the second highest cause of years of life lost (Organization, 2014; Radin et al., 2012; Nair et al., 2011). Severe influenza di

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