• br Ketone bodies in a cell

  2018-11-06

  

  Ketone bodies in a cell culture model of AD Neuroprotective properties of ketone bodies have been investigated in cell cultures. A proteolytic fragment of the β chain of amyloid precursor protein, Aβ1–42, is toxic to hippocampal cells. The exposure of 6-day cultured hippocampal neurons from 18-da

• RG cells have been generated from a variety of different

  2018-11-06

  

  RG cells have been generated from a variety of different sources of embryonic and adult brains, and embryonic stem cells (Conti et al., 2005; Liour and Yu, 2003; Bibel et al., 2004; Malatesta et al., 2000). In addition to isolating RG cells from human fetal tissue (Mo et al., 2007), it has recently

• Gene expression is regulated by complex coordinated

  2018-11-06

  

  Gene expression is regulated by complex coordinated processes, including chromatin remodeling, post-translational modifications of histones, and incorporation of non-allelic histone variants. The histone variant H2AZ constitutes only a few percents of the total H2A cellular pool (). However, H2AZ is

• Introduction Induced pluripotent stem cells iPSC

  2018-11-06

  

  Introduction Induced pluripotent stem gallic acid (iPSC) have been used in an increasing number of applications since Takahashi and Yamanaka (Takahashi and Yamanaka, 2006) first demonstrated the reprogramming of adult somatic cells to produce iPSC. In combination with gene editing technology iPSC

• Epiretinal transplantation does not involve retinal detachme

  2018-11-06

  

  Epiretinal transplantation does not involve retinal detachment and may cause less trauma to the retina as compared with subretinal cell delivery. However vitreous detachment in patients causes increased photopsias, floaters and increased risk of retinal detachment and macular holes (de Smet et al.,

• The gene expression changes that occurred

  2018-11-06

  

  The gene expression changes that occurred during the differentiation process were consistent with our expectations of changes that must occur during neurogenesis. For example, there was a positive enrichment for genes involved in synaptogenesis and a negative enrichment for genes involved in progres

• Progress in the field of neuronal replacement using

  2018-11-06

  

  Progress in the field of neuronal replacement using NT2 committed to differentiate with retinoic Z-VDVAD-FMK (RA) is limited by the long time frame necessary to generate postmitotic NT2N neurons and also by the low proportion of terminally differentiated neurons. Thus, neuronal differentiation of N

• br Conclusion Cellular reprogramming is an inefficient proce

  2018-11-06

  

  Conclusion Cellular reprogramming is an inefficient process and obtaining the rare reprogramming intermediates is a major hurdle in understanding this important event at the molecular level. The application of certain techniques that require higher cell numbers such as transcription factor Aproti

• To evaluate global gene expression patterns in the

  2018-11-05

  

  To evaluate global gene expression patterns in the mutant cells, we performed RNA sequencing (RNA-seq) on control and the three RB1−/− clones. Of the expressed transcripts, 4.8% were either 2-fold upregulated or downregulated in the RB1−/− clones. In contrast to the absence of pRB due to frameshift

• The experimental data of Ref

  2018-11-05

  

  The experimental data of Ref. [32] prove that the yield point is particularly strongly dependent on hydrogen concentration. A linearly elastic material may be logically assumed to have a free surface area that, for small strains, is proportional to the deformation itself. Consequently, the α and β

• br Conclusion The Hartree Fock approach was used for

  2018-11-05

  

  Conclusion The Hartree–Fock approach was used for finding wave functions and single-electron energies of the sodium THZ531 in the ground and the excited states. The photoionization amplitudes and the photoabsorption cross-sections for this atom were computed through RPAE which explains the exper

• The results of the fully adjusted multivariate models for

  2018-11-05

  

  The results of the fully adjusted multivariate models for sickness benefit and disability pension are shown in Table 3. These results were very similar when estimated without adjustment for explanatory variables other than age and year of observation. Overall, they suggest no support for the argumen

• Use of different types of government metrics may yield

  2018-11-05

  

  Use of different types of government metrics may yield important findings. Bischoff (2008) reported that the proliferation of school districts increase multiracial segregation between districts. In the historical data of government census, school districts showed a different pattern of growth from o

• br Methods br Results br Discussion Sequencing of the

  2018-11-05

  

  Methods Results Discussion Sequencing of the first human genome took more than a decade, completing in 2001, and costing more than US$2.7 million (Lander et al., 2001; Venter et al., 2001; NHGRI, 2010). In the subsequent decade, newer high-throughput genomic technologies, known as the Next-

• The additive impact of progressive changes in sleep quality

  2018-11-05

  

  The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow, neurovascular and neurotransmitters, plus the cellular redox status are all likely to contribute to the cognitive deficits reported in up to one out of four newly diagnosed OSA patients (Rosenz

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