• Recent studies have shown that

  2018-10-29

  

  Recent studies have shown that 5mC can be oxidized to 5-hydroxymethycytosine (5hmC) by TET enzymes and that this process may play a role in global DNA demethylation during preimplantation development and in the germline (Tahiliani et al., 2009; Iqbal et al., 2011; Hackett et al., 2013). Conversion o

• To determine if subepithelial cells such as SEMFs are

  2018-10-29

  

  To determine if subepithelial cells, such as SEMFs, are a required physiologic Wnt source, we used Myh11-Cre mice. Myh11-encoded smooth-muscle myosin heavy chain is expressed in much of the intestinal subepithelium (Wirth et al., 2008). To define the precise expression domain, we crossed Myh11-Cre t

• br Resource table br Resource

  2018-10-26

  

  Resource table Resource details We generated KCL028 research grade hESC line following protocols, established previously (Ilic et al., 2012; Stephenson et al., 2012). The expression of the pluripotency markers was tested after freeze/thaw cycle (Ilic et al., 2012). Differentiation potential

• The fate of hESC derived pancreatic progenitor

  2018-10-26

  

  The fate of hESC-derived pancreatic progenitor cells differed substantially following transplantation in SCID-beige mice versus nude rats. As early as 19 weeks post-transplantation, rats had significantly lower fasting human C-peptide levels and enhanced meal- and glucose-responsive C-peptide secret

• br Results br Discussion In

  2018-10-26

  

  Results Discussion In this study we provide several lines of evidence that Dnd serves as a critical PGC specifier in medaka. First, dnd knockdown is capable of specifically and completely abolishing PGC formation and its overexpression is sufficiently capable of inducing ectopic PGCs in embryo

• Because the process of dedifferentiation

  2018-10-26

  

  Because the process of dedifferentiation through the addition of Yamanaka factors is extremely inefficient, the actual contribution of de novo generated “CSC states” via oncometabolic reprogramming to cancer evolution might be a matter of conjecture. To evaluate such a situation, we first confirmed

• br Experimental Procedures br Author Contributions N

  2018-10-26

  

  Experimental Procedures Author Contributions N.N.G. performed most of the experimental work, with the help of M.G., J.L., and P.G.P. C.S.J. helped perform in vivo cell transplantation experiments. S.A.M. and F.R. were responsible for inducible Pax7 lineage-tracing experiments. A.A. performed q

• br Results br Discussion br Experimental

  2018-10-26

  

  Results Discussion Experimental Procedures Author Contributions Acknowledgments The authors thank Robbert Zalm for cloning and producing viral particles, Frank den Oudsten for producing glia feeders, Rien Dekker for expert assistance in electron microscopy, and members of the CNCR iPS

• The nanofilm refractive index n and the

  2018-10-26

  

  The nanofilm refractive index n and the thickness d (in nm) were measured with the use of a spectral ellipsometer HORIBA Jobin Yvon. Integral light transmission T (in %) of nanocomposite samples in the visible spectral range of 400–800 nm was recorded with a microspectrometer FSD-8 and processed wit

• The gene of the sigma

  2018-10-26

  

  The gene of the sigma-1 receptor is located on chromosome 9p13, known due to its being associated with psychotic disorders [6]. The sigma-1 receptor, with its small size (223 amino-acid residue), binds with medium or high affinity to a wide range of chemical compounds of very different structural cl

• To determine whether economic psychological and

  2018-10-26

  

  To determine whether economic, psychological, and neighborhood indices explain excess risk by race/ethnicity in high AL, we fit a series of linear regression models, with results displayed in Tables 3 and 4. We focused on the proportion of excess risk in high AL by race/ethnicity that was explained

• br Introduction Vaccination is a vital public

  2018-10-26

  

  Introduction Vaccination is a vital public health intervention for the prevention of communicable diseases. Its effectiveness has been demonstrated by the eradication of smallpox, the near eradication of poliomyelitis and significant reductions in the incidence of vaccine preventable diseases (WH

• br Author contributions br Funding C W F

  2018-10-26

  

  Author contributions Funding C.W.F. is a contractor of the US National Institute of Diabetes, Digestive and Kidney Diseases, National Institute of Health (HHSN 276201200161U). The funding source had no role in study design, data interpretation, or manuscript preparation. Conflict of interes

• br Methods br Results In

  2018-10-26

  

  Methods Results In 1860 there were 1100 counties within the boundaries of states legally permitting slavery (Upper South: 621; Deep South: 479), and in 2010 these same states consisted of 1,347 counties or county equivalents (716 and 624 for the Upper and Deep South, respectively). Spatial int

• br Method br Results Descriptives and bivariate

  2018-10-26

  

  Method Results Descriptives and bivariate correlations of all study variables are presented in Table 2, separately for men and women. Tests for the significance of differences between men and women are presented in Table 3. Gender differences were observed for all study variables, except age a

15857 records 1050/1058 page Previous Next First page 上5页 10461047104810491050 下5页 Last page