• In regards to regional variation in metabolic behavior of ad

  2021-03-23

  

  In regards to regional variation in metabolic behavior of adipose tissue, subcutaneous adipose tissue transplantation has been shown to reprogram visceral adipose tissue to have subcutaneous-like phenotypic behavior, whereas visceral-to-subcutaneous transplantation does not promote a more detriment

• Circulating NK subsets also show considerable differences in

  2021-03-23

  

  Circulating NK subsets also show considerable differences in homing molecules. CD56bright Okadaic acid express the chemokine receptor CCR7 and L-selectin, which drive their migration to secondary lymphoid organs (Fehniger et al., 2003). In contrast, CD56dim display a high density of CX3CR1 and CXCR

• br E E backside interaction The E possesses

  2021-03-23

  

  E3–E2 backside interaction The E2 possesses an important regulatory interface which is termed its backside as it is opposite to the catalytic cleft that bears the active-site cysteine forming the thioester with SUMOD. This backside site interacts noncovalently with a scaffold SUMOB and was origin

• Recent results from our group found that

  2021-03-23

  

  Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet monocarboxylate transporters to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the conjunctiva

• N acetylation by N acetyltransferase NAT

  2021-03-23

  

  N-acetylation by N-acetyltransferase (NAT) is an important metabolic pathway for some substances, and there are 2 functional NAT isoforms in humans—NAT1 and NAT2. Studies of etamicastat in healthy subjects showed an extensive N-acetylation of etamicastat to the inactive metabolite BIA 5-961, and a l

• CellProfiler and OpenComet are two open

  2021-03-23

  

  CellProfiler and OpenComet are two open source software available in internet to analyse silver stained comet assay images. With CellProfiler [19], Gonzalez et al. [18] modified the pipeline provided in the website by adding a background subtraction module and two filtering modules to quantify DNA d

• The unique property of mutant IDH in producing an oncometabo

  2021-03-23

  

  The unique property of mutant IDH1/2 in producing an oncometabolite that has no known physiological function makes mutant IDH enzymes as obvious potential therapeutic targets for the treatment of IDH-mutated tumors (Rohle et al., 2013, Wang et al., 2013). Clinical studies have also suggested the pre

• br Endothelial mechanotransduction br Apoptosis br Death ass

  2021-03-23

  

  Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the LEE011 network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endothelial cells DAPK

• Pathological changes in animal are powerful

  2021-03-23

  

  Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin

• Fatty acid oxidation plays a

  2021-03-22

  

  Fatty 3-isomangostin synthesis β-oxidation plays a crucial role in maintaining body energy homoeostasis mainly during catabolic states. It mainly occurs in mitochondria and involves a cyclical series of reactions that result in the shortening of fatty acids. Fatty acids comprise an efficient source

• Animal studies investigating the role of D

  2021-03-22

  

  Animal studies investigating the role of D1 dopamine receptors in the PFC have focused on delayed response tasks, which require online maintenance of a previously presented stimulus. Striatal dopamine is thought to be important for flexibility and updating goal representations when new information i

• Clozapine N-oxide Rat pheochromocytoma PC cells have been wi

  2021-03-22

  

  Rat pheochromocytoma PC12 cells have been widely used as a cell system to study intracellular signaling leading to neurite outgrowth. The advantages of using PC12 cells in the CHK studies are the fact that they naturally express the rat form of CHK and the observation that down-regulation of CHK fun

• Modulating protein stability specifically inhibiting ubiquit

  2021-03-22

  

  Modulating protein stability, specifically inhibiting ubiquitin E3 ligases, provides potential advantages over other druggable targets given the presence of biochemically multiple, unique pharmacophores within complexes that can bind a variety of small molecules [12]. The FBXO3 inhibitors used here

• br Methods br Results br Discussion

  2021-03-22

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific next organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Liguori,

• br Material and methods br

  2021-03-22

  

  Material and methods Results Discussion In the present study, twenty strains of Y. enterocolitica were analyzed for their inhibitory potential on cysteine proteases. Five of these strains belonged to bioserotype 4/O:3, which is distinguished for its pathogenicity towards humans. The rest of

15781 records 662/1053 page Previous Next First page 上5页 661662663664665 下5页 Last page