• To elucidate whether the impact of hypoxia on EGFR

  2021-02-08

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer GFP Quantitation Kit driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and

• To assess whether the described

  2021-02-08

  

  To assess whether the described cooperation between the EGFR and FGFR receptors was relevant at the clinical level, we determined the effect on progression-free survival of FGFR1 expression in patients with adenocarcinoma who were receiving erlotinib or gefitinib. As we had observed EGFR-FGFR1 coope

• Our study provides proof of principle for dimerizing

  2021-02-08

  

  Our study provides proof of principle for dimerizing two different E3 ligases as a novel approach to inducing one ligase to degrade the other one. The outcome of ‘ligase versus ligase’ PROTAC-mediated activity might be unpredictable a priori, but could reveal a new mechanism for proximity-mediated h

• br RING dimerization RING type domains are

  2021-02-08

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain Amikacin (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (sho

• Coumarin Historically covalent drugs have had

  2021-02-08

  

  Historically, covalent drugs have had great success (e.g., aspirin and penicillin), and covalent drugs have become a focus in anticancer and antiviral drug discovery (Kalgutkar and Dalvie, 2012, Singh et al., 2011). These compounds contain low reactivity warheads that allow covalent adducts to form

• br Experimental Procedures br Author Contributions br Acknow

  2021-02-08

  

  Experimental Procedures Author Contributions Acknowledgments Research in the Davis laboratory was supported by grants 4R37NS019904, 5R01NS052351, and 1R35NS097224 from NINDS. Research in the Martemyanov laboratory was supported by grants DA036596 and DA026405 from NIDA, and MH105482 from NI

• Because conventional KO mice die within h of birth

  2021-02-08

  

  Because conventional KO mice die within 24h of birth, it is difficult to analyze higher C527 functions using them. Therefore, in this study, we generated brain-specific conditional DGKδ-KO mice and used these mice to perform behavioral and pharmacological tests. Results Discussion OCD is a p

• br Introduction br Literature review and hypothesis developm

  2021-02-07

  

  Introduction Literature review and LX7101 HCL development CPA exam performance-related research has been of interest to academics for the past few decades. These studies have ranged from investigating the impact of the 150-hour requirement on pass rates (Allen & Woodland, 2006) to examining w

• Materials and methods br Results

  2021-02-07

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino Bikinin for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the existing tr

• Two additional hydrogen bonds are formed by the

  2021-02-07

  

  Two additional hydrogen-bonds are formed by the -substituted methoxy-group with Ser and Asp. Ser exerts the role of a gate keeper in CK1: Entry of the ATP in the binding-site causes a conformational change into the closed form by Ser, which locks the binding-site and prevents ATP-diffusion out of th

• In our previous research we have focused on

  2021-02-07

  

  In our previous research, we have focused on the discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Numbers of biphenyl-aryl urea incorporated with salicylaldoxime including BPS-7 have been developed as potent and selective VEGFR-2 inhibitors (Fig. 3) [12], [13], [14], [15], [16], [1

• EPAC induces SOCS gene expression in VECs

  2021-02-07

  

  EPAC1 induces SOCS3 gene expression in VECs, resulting in suppression of the JAK–STAT activation initiated by the sIL-6Rα/IL-6 trans-signalling complex [67]. EPAC1 regulates SOCS3 gene induction through the activation of C/EBP and c-Jun transcription factors, which interact directly with the SOCS3 p

• br Acknowledgments The research in

  2021-02-07

  

  Acknowledgments The research in this study was supported by grants from CMHS, UAE University and Qatar University. The authors gratefully acknowledge Dr. R Lukas (Barrow Neurological Institute, Phoenix, AZ, USA) for SH-EP1 guggulsterone stably expressing the human α7 nACh and human α4β2 nACh rec

• It is known that cigarette smoke

  2021-02-07

  

  It is known that cigarette smoke increases the oxidative burden in the lungs of mice with emphysema, which leads to oxidative stress [[34], [35], [36]]. However, in addition to cigarette smoke, studies have shown that endogenous oxidative stress is associated with proteolytic N,N-Dimethylsphingosine

• br Acknowledgments br Multicellular organisms respond

  2021-02-07

  

  Acknowledgments Multicellular organisms respond rapidly, and adapt to cellular stress to maximize cell survival. The cellular stress response, also called (ISR), is universally conserved and independent of the stressor. ISR induces rapid, transient reprogramming of cellular protein translation

15686 records 682/1046 page Previous Next First page 上5页 681682683684685 下5页 Last page