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br Conflicts of interest br Acknowledgements
2019-08-29
Conflicts of interest Acknowledgements Introduction Atherosclerosis is the number one cause of death in the United States and among the leading causes of morbidity and mortality globally [1]. Inflammation is critical in all stages of atherosclerosis from the formation of a plaque in the ves
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FOX proteins constitute a large class of transcription facto
2019-08-29
FOX proteins constitute a large class of transcription factors with multiple functions, from development and organogenesis to regulation of metabolic and immune functions. The Fox transcription factor is characterized by a 100-amino-acid wing helix or forkhead DNA-binding domain. In addition, the FO
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br Acknowledgements br Introductio http www
2019-08-29
Acknowledgements Introduction TB is also widely prescribed as a stain to identify proteoglycans and glycosaminoglycans (GAGs) in agarose gel electrophoresis (Dietrich and Dietrich, 1976; Coulson-Thomas et al., 2015). In addition, as adjunct to a photodynamic antimicrobial chemotherapy assay, T
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br Discussion We are reporting a cryptic insertion
2019-08-28
Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in Acarbose mass exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnormality [6
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br Multi subunit RINGs There
2019-08-28
Multi-subunit RINGs There are RING-type E3s that exist as multi-subunit assemblies (see Fig. 3B). A striking example is the Cullin RING Ligase (CRL) superfamily [35], which exhibits enormous plasticity in substrate specificity. Each CRL subfamily is characterized by a cullin protein (Cul-1, 2, 3,
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In the present study DRD decreased in the
2019-08-28
In the present study, DRD3 decreased in the VTA of OA when compared with the control group. It is reported that DRD3 in the VTA control the firing rate of dopaminergic neurons and inhibition of these receptors enhance firing in the VTA-projecting neurons [18]. A study also indicated that morphine tr
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Docetaxel Mammalian cells have two distinct DNA repair pathw
2019-08-28
Mammalian Docetaxel have two distinct DNA repair pathways for DSBs, NHEJ and HR. Our data are consistent with the suggestion that the DNA–PK-mediated NHEJ pathway recognizes DSBs faster than the HR pathway and acts before the activation of the DNA damage S-phase checkpoint. The activation of NHEJ b
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br Introduction Vitis vinifera L
2019-08-28
Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat
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In general the DNMT encompass three different
2019-08-28
In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated
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We also performed a correlation analysis
2019-08-28
We also performed a correlation analysis independent of annotated gene sets to identify potentially novel genes that are co-expressed with DHODH. Using the top 100 DHODH co-expressed genes in COAD, LGG, STAD, and PAAD diseases, we identified four common genes across all four diseases (Fig. 9). These
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In normal chow fed mice EP deficiency
2019-08-27
In normal chow fed mice, EP4 deficiency also decreased the expression of CYP8B1, the downstream target of CYP7A1. Similarly, knockdown of EP4 with small interfering RNA reduced the expression of CYP8B1 in HepG2 cells. Therefore, it was anticipated that there would be an increased expression of CYP8B
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Finasteride kinase br Conclusion br Conflict of interest br
2019-08-27
Conclusion Conflict of interest Acknowledgment The authors acknowledge the grant support of the Tehran University of Medical Sciences (94-02-49-29647). Introduction Earlier in vitro observations have also established that the human 5-HT2A, while very similar to the rat isoform, exhibits
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The DDR mediated lysyl oxidase induction in
2019-08-27
The DDR2-mediated lysyl oxidase induction in osteoblasts reported here is a novel function for this receptor. Various functions have been reported for DDR2. In an in-vitro study, Zhang and colleagues showed that DDR2 activation leads to Runx2 phosphorylation, which regulates osteoblast differentiati
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Recent studies have shown arsenic could
2019-08-27
Recent studies have shown arsenic could cause autophagic cell death in malignant cells, including leukemia and malignant glioma Biotin-azide and [16], [17]. However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related pro
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The detection of galactomannan GM a polysaccharide that
2019-08-27
The detection of galactomannan (GM), a polysaccharide that is released during Aspergillus growth, is a useful and reliable non-invasive diagnostic test for screening and management of aspergillosis and is often more sensitive than culture (Schelenz et al., 2015, Fisher et al., 2013). The level of ga
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