• From an evolutionary perspective the high level of

  2018-11-08

  

  From an evolutionary perspective, the high level of resistance of HSPCs to lentiviruses makes sense, since any major chromosomal vulnerability would have more serious implications than in progeny cells. The high-level expression of SAMHD1 in cultured HSPCs is reminiscent of the one in activated CD4+

• While we showed that endothelial cells and

  2018-11-08

  

  While we showed that endothelial protein kinase g and astrocytes contribute to the regulation in the neurogenic niche of the hippocampus, the role of pericytes is far less conclusive. For most time pericytes have received relatively little attention and only more recently their role in the context

• Introduction The stem cell subset contained within the

  2018-11-08

  

  Introduction The stem cell subset contained within the bone marrow stromal cell population (BMSCs, also known as bone marrow-derived mesenchymal stem cells) is characterized by self-renewal capacity, clonogenicity in vitro, multipotent differentiation into mesoderm-type gssg including osteoblast, a

• sirtuin 1 In the current study we compared two different gen

  2018-11-08

  

  In the current study, we compared two different genetic backgrounds on the induction and maintenance of multipotency by generating clonal iNSC lines from two distinct mouse strains (C57BL/6 vs. C3H). Clonal iNSC lines from distinct genetic backgrounds exhibited the distinct levels of conversion effi

• br Conclusion br Contributions br Competing interests br

  2018-11-08

  

  Conclusion Contributions Competing interests Funding This study was financially supported by German Academic Exchange Service/Federal Ministry of Education and Research (grant # D/09/04774), Center for Regenerative Therapies Dresden (Seed Grant # 09-08), Simon Fougner Hartmanns Family Fo

• The last aspect we want to address

  2018-11-08

  

  The last aspect we want to address in this review is the importance of suitable cell culture conditions for targeting and single cell cloning of human PSCs. This is probably the most challenging aspect since there are significant variances between different human PSC clones concerning proliferation,

• Interestingly in HCC cell lines the overexpression

  2018-11-08

  

  Interestingly, in HCC cell lines the overexpression of SOX2 correlated with an increased cell invasion and sphere formation ability (Sun et al., 2013), suggesting a connection to an EMT and CSC phenotype. In HCC patients, SOX2 expression predicted poor overall survival and prognosis even after hepat

• These differentiated HLCs retain a strong fetal and immature

  2018-11-08

  

  These differentiated HLCs retain a strong fetal and immature phenotype, as demonstrated by the persistence of alpha-fetoprotein (AFP) and diminished hepatic functions when compared to primary adult hepatocytes (PHHs). Strategies to improve the differentiation protocol are being explored. For example

• miR a has been extensively studied

  2018-11-08

  

  miR-29a has been extensively studied in different fields. miR-29a has been reported to be associated with cardiac hypertrophy and fibrosis (Roncarati et al., 2014), and functions as a negative regulator of extracellular matrix remodeling (van Rooij et al., 2008). We have previously reported that miR

• SATB acts as a master regulator by binding to genes

  2018-11-08

  

  SATB2 acts as a master regulator by binding to genes which regulate embryonic development, cell differentiation, pluripotency, and cell survival (Ordonez, 2014; Rosenfeld et al., 2009; Zhao et al., 2014). We have discovered the SATB2 buy d-amphetamine in the promoters of c-Myc, Nanog, Kl4, Bcl-2 an

• br Acknowledgement Our work is supported

  2018-11-08

  

  Acknowledgement Our work is supported by research grants from the Agence Nationale de la Recherche (ANR; projects PLURABBIT no. PCS-09-GENM-08 and ORYCTOGENE no. ANR-12-RPIB-0013), European Cooperation in Science and Technology (COST) Action (Rabbit Genome Biology (RGB)-Net no. TD1101), HyPharm,

• The numbers of GFAP NSCs did not return

  2018-11-08

  

  The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

• Importantly we found that both HIF factors nonredundantly re

  2018-11-08

  

  Importantly, we found that both HIF factors nonredundantly regulate the morphology and behavior of primary mesenchymal progenitors: in the absence of HIFα expression PαS+ mesenchymal progenitors show impaired proliferation, colony forming ability, and differentiation and acquire an elongated and mot

• In conclusion our experimental setting allowed

  2018-11-08

  

  In conclusion, our experimental setting allowed the identification of differences in survival and proliferation pathways between PN and MES GSCs. The sensitivity of MES GSCs to the silencing of AXL highlights its importance in this subgroup of GSCs and suggests its potential for use as a therapeutic

• bcl-2 inhibitor br Conclusion In this study we have successf

  2018-11-08

  

  Conclusion In this study we have successfully generated iPSCs, and iPSC-derived retinal organoids, from patients with TRNT1-associated RP and used these bcl-2 inhibitor to investigate the underlying pathophysiologic mechanisms of disease. We have also identified disease-specific phenotypes that p

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