• The gene expression changes that occurred

  2018-11-06

  

  The gene expression changes that occurred during the differentiation process were consistent with our expectations of changes that must occur during neurogenesis. For example, there was a positive enrichment for genes involved in synaptogenesis and a negative enrichment for genes involved in progres

• Progress in the field of neuronal replacement using

  2018-11-06

  

  Progress in the field of neuronal replacement using NT2 committed to differentiate with retinoic Z-VDVAD-FMK (RA) is limited by the long time frame necessary to generate postmitotic NT2N neurons and also by the low proportion of terminally differentiated neurons. Thus, neuronal differentiation of N

• br Conclusion Cellular reprogramming is an inefficient proce

  2018-11-06

  

  Conclusion Cellular reprogramming is an inefficient process and obtaining the rare reprogramming intermediates is a major hurdle in understanding this important event at the molecular level. The application of certain techniques that require higher cell numbers such as transcription factor Aproti

• To evaluate global gene expression patterns in the

  2018-11-05

  

  To evaluate global gene expression patterns in the mutant cells, we performed RNA sequencing (RNA-seq) on control and the three RB1−/− clones. Of the expressed transcripts, 4.8% were either 2-fold upregulated or downregulated in the RB1−/− clones. In contrast to the absence of pRB due to frameshift

• The experimental data of Ref

  2018-11-05

  

  The experimental data of Ref. [32] prove that the yield point is particularly strongly dependent on hydrogen concentration. A linearly elastic material may be logically assumed to have a free surface area that, for small strains, is proportional to the deformation itself. Consequently, the α and β

• br Conclusion The Hartree Fock approach was used for

  2018-11-05

  

  Conclusion The Hartree–Fock approach was used for finding wave functions and single-electron energies of the sodium THZ531 in the ground and the excited states. The photoionization amplitudes and the photoabsorption cross-sections for this atom were computed through RPAE which explains the exper

• The results of the fully adjusted multivariate models for

  2018-11-05

  

  The results of the fully adjusted multivariate models for sickness benefit and disability pension are shown in Table 3. These results were very similar when estimated without adjustment for explanatory variables other than age and year of observation. Overall, they suggest no support for the argumen

• Use of different types of government metrics may yield

  2018-11-05

  

  Use of different types of government metrics may yield important findings. Bischoff (2008) reported that the proliferation of school districts increase multiracial segregation between districts. In the historical data of government census, school districts showed a different pattern of growth from o

• br Methods br Results br Discussion Sequencing of the

  2018-11-05

  

  Methods Results Discussion Sequencing of the first human genome took more than a decade, completing in 2001, and costing more than US$2.7 million (Lander et al., 2001; Venter et al., 2001; NHGRI, 2010). In the subsequent decade, newer high-throughput genomic technologies, known as the Next-

• The additive impact of progressive changes in sleep quality

  2018-11-05

  

  The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow, neurovascular and neurotransmitters, plus the cellular redox status are all likely to contribute to the cognitive deficits reported in up to one out of four newly diagnosed OSA patients (Rosenz

• The virus tested in this

  2018-11-05

  

  The virus tested in this study is one of a family of genetically engineered viruses designed for specific infection and killing of cancer. These were meant as therapeutic agents. In preclinical studies, these viruses infect and kill many cancer cell lines, including many pancreatic cancer cell lines

• Gut Microbiome and Inflammatory Bowel Disease

  2018-11-05

  

  Gut Microbiome and Inflammatory Bowel Disease Modulation of Gut Microbiota in Obesity and Cardiometabolic Disorders Changes in gut microbiota are associated with metabolic disorders such as obesity, type 2 diabetes and cardiovascular risk factors. Patrice D. Cani (Brussels, Belgium), Willem M. d

• The lack of such stratification

  2018-11-05

  

  The lack of such stratification may underlie the inconsistent data from trials of LMWH for PMPC (Martinelli et al., 2012; Rodger et al., 2014) due to inclusion of heterogeneous disease mechanisms rather than a focus on those associated with a procoagulant mechanism. These findings also suggest that

• br Limitations and future lines of investigation

  2018-11-05

  

  Limitations and future lines of investigation This exploratory study has a series of limitations. First, the use of a sample of university students from a specific school can affect the external validity of the results. Second, we studied parental influence in only one region of Spain. Thus, a co

• Hypocretinergic activation during REM sleep

  2018-11-05

  

  Hypocretinergic activation during REM sleep is likely related to the activation that occur during certain patterns of somatomotor activity [50]. Although motor output is inhibited at the motoneuron level during REM sleep, supraspinal motor systems are very active during this state [60–62]. In fact,

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